The Millhauser Lab Prions, Alzheimer's Disease, EPR, NMR
|Misfolding of PrPC
causes prion diseases, which include
kuru, CJD and mad cow disease.
PrP's normal function is related to
copper and zinc regulation in the
central nervous system. Cu2+
promotes an interaction between the
protein's domains that suppresses
inherent neurotoxicity. (J.
Mol. Biol. 432:4408-25 2020,
Enzymol. 666:297-314 2022)
PrPC is a primary receptor for the Aβ peptide and its aggregates, which form senile plaques that initiate Alzheimer's disease. Confocal microscopy shows that Aβ with a fluorescent tag (green) is imported into PrP expressing cells. (PNAS 117:28625-31 2020).
Department of Chemistry & Biochemistry
University of California, Santa Cruz
Santa Cruz, CA 95064
glennm at ucsc.edu
office phone 831 459 2176
lab phone 831 459 3390
fax 831 459 2935
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